is it be able to use USB Mouse and USB Keyboard on same time ?
(USB Hub ?)
It doesn't have a hub built in but you can connect a hub or a KVM.
I actually don't know how much it would cost to build in a hub but hubs really don't cost that much generally.
Currently with the USB-2-232 it has some handling caked in for keyboards so it knows to ignore them but it is able to know it has both a keyboard and mouse plugged in. if it didn't then it would probably crash when connected to a KVM.
I should probably note that in the default TinyUSB lib, one hub does work but nested hubs do not. Which is why I had issues with KVM's. The modified version of TinyUSB is able to handle a chain of I think 10 4 port hubs, though I think I limited that for the sake of ram.